At 40, Dr. Keegan Wade is the Chief of Trauma Surgery, a rising star at NYC General. She's immersed 24-7 in work that she once loved. No one waits for her at home and she has nothing to offer. Anxiety has her in a chokehold and she'd give anything to sleep more than two consecutive hours. At the urging of a friend, she takes a long overdue vacation, a cross country trip on a restored steam train, in hopes that time away from the pressures of her job will solve her problems.
At 39, Willow Lord is a recent college graduate, a social worker in desperate need of a job. Divorced nine years, she's lived in poverty, saving coins to buy cat food. Next month, the first payments on her student loans are due. She has no time for a vacation, but when her friend, a friend who won't take 'no' for an answer insists, she sends out resumes and boards The Frisco Express—New York City to California.
As girls, they met and fell in love. But, circumstances set them on separate paths. Twenty-six years later, they board The Frisco Express, and love is given a second chance.